Our laboratory is integrated in the Institute for Biotechnology and Biomedicine and in the Graduate Program in Basic and Applied Neurosciences of the Universitat de València. Our lab is associated to the Spanish Research Network on Mental Health (CIBERSAM, G23) and the Fundación de Investigación del Hospital Clínico Universitario de Valencia INCLIVA. We are also integrated into the research microcluster “Information & control technologies applied to the patophysiology of diabetes” in the VLC/Campus of Excellence.
The main objective of our research group is to investigate the structural plasticity of the adult brain, particularly of inhibitory neurons. We analyze this process at the level of synaptic reorganization, neurite and spine remodeling and neuronal production/incorporation. Molecules involved in this plasticity are also studied in the lab. We are particularly interested in how this structural plasticity is involved in psychiatric disorders, such as schizophrenia, bipolar disorder or major depression and their treatment. To achieve this objective we use animal models of these disorders and postmortem material from psychiatric patients. We use different strains of mice expressing fluorescent proteins in selected neuronal populations to visualize structural remodeling, both in fixed tissue and in real time, using organotypic cultures and cerebral windows.
- Just published!!
Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex.J Neurosci. 2020 Jun 24;40(26):5008-5018