Our laboratory is integrated in the Neurobiology Unit of the Cell Biology Dpt. and in the Graduate Program in Basic and Applied Neurosciences of the Universitat de València. We are also integrated into the research microcluster “Information and control technologies applied to the patophysiology of diabetes” in the VLC/Campus of Excellence. Our lab is associated to the Spanish Research Network on Mental Health (CIBERSAM) and the Fundación de Investigación del Hospital Clínico Universitario de Valencia INCLIVA
The main objective of our research group is to investigate the structural plasticity of the adult brain. We analyze this process at the level of synaptic reorganization, neurite and spine remodeling and neuronal production/incorporation. We are particularly interested in how this structural plasticity is involved in psychiatric disorders, such as schizophrenia and major depression and their treatment. To achieve this objective we use animal models of these disorders and postmortem material from psychiatric patients. We use different strains of mice expressing fluorescent proteins in selected neuronal populations to visualize structural remodeling, both in fixed tissue and in real time, using organotypic cultures and cerebral windows.
Our research is supported mainly by the Spanish Ministry of Economy and Competitiveness and the Generalitat Valenciana. We are integrated in an European ERA-NET project “Neuconnect”, which main objective is to understand the involvement of the neural cell adhesion molecule (NCAM) and its posttranslational modifications in schizophrenia. We have also received funding from the Stanley Research Foundation to analyze the expression of molecules related to neuronal structural plasticity in the brain of psychiatric patients and recently from the Fundación Alicia Koplowitz to study the influence of cannabis comsumption during the adolescence in the development of schizophrenia.